cancer therapy
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Cancer is a disease ascribing more that 200 sub-pathologies. Many more anticancer strategies are available both from official or alternative- complementary medicine. Here we discuss a possible general strategy of intervention, based on rationals which should be considered...
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"The monks technique had the authority of Hippocrates and Galen, the ancient writers on medicine, and everyone agreed they must be right."
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Cancer in pets is a spontaneous disease, as for humans. Living in the same environment, pets are exposed to the same carcinogens that plague us.
Crude estimates of cancer incidence in the U.S. indicate that there are roughly 6 million new cancer…
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lThe concept of Immunotherapy is based on the body's natural defense system, which protects us against a variety of diseases. Although we are less aware of it, the immune system also works to aid our recovery…
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At present therapeutic protocols are much articulated. Usually they use conbinations of surgery, radiotherapy and chemotherapy. Target therapy is currently the new frontier and companies are developing molecules "specifically" (almost, in many cases..) directed against molecular features of tumors.Nanotech…
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immunotherapy
Many years ago, diphtheria toxin (DT) showed antitumor activity in mice and in humans, but it was unclear whether this depended on the toxicity of the molecule only or on its strong inflammatory-immunological property as well. (Buzzi S., Cancer Res. 1982 May;42(5):2054-8). The same researchers, to deal with this open question, planned to treat a group of cancer patients with cross-reacting material 197 (CRM197).
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...The once-weekly injection of minute amounts of Gc-MAF, just 100 nanograms (billionths of a gram), activates macrophages and allows the immune system to pursue cancer cells with vigor, sufficient to produce total long-term cures in humans..."
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A report on the creation of a virus obtained genetically modifying a common adenovirus which could constitute a therapy against cancer has appeared recently in the scientific news. This virus would selectively infect cancer cells and force them to express a protein which calls for the intervention of macrophages, additionally stimulating them to multiply. This strategy would therefore help the body mounting a strong immune response against cancer cells.
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Cancer can spread only after having won the fight against the immune system. In the years scientists have discovered a number of strategies put in place by cancer cells to sneak out of the control of the immune system or even to counterfight it. Macrophages, a fundamental arm of immunity, should be put off for cancer affirmation.
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They are key determinants in autoimmunity but have been indicated to play a crucial role in cancer immune-evasion (Franzke A, Hunger JK, Dittmar KE, Ganser A, Buer J Regulatory T-cells in the control of immunological diseases. Ann Hematol. 2006 Nov;85(11):747-58. Epub 2006 Jul 27). Increasing evidences support the existence of elevated numbers of these regulatory Treg cells in solid tumors and hematological malignancies.
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Cancer and evolution
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EurekAlert! - Cancer
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The premier online source for science news since 1996. A service of the American Association for the Advancement of Science.
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Moffitt Cancer Center researchers identify genetic variants predicting aggressive prostate cancers
(H. Lee Moffitt Cancer Center & Research Institute) Researchers at Moffitt Cancer Center and colleagues at Louisiana State University have developed a method for identifying aggressive prostate cancers that require immediate therapy. It relies on understanding the genetic interaction between single nucleotide polymorphisms. The goal is to better predict a prostate cancer's aggressiveness to avoid unnecessary radical treatment.
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Genetics of cervical cancer raise concern about antiviral therapy in some cases
(Oregon State University) A new understanding of the genetic process that can lead to cervical cancer may help improve diagnosis of potentially dangerous lesions for some women, and also raises a warning flag about the use of anti-viral therapies in certain cases -- suggesting they could actually trigger the cancer they are trying to cure.
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Biologists identify the chemical behind cancer resistance in naked mole rats
(University of Rochester) Two researchers at the University of Rochester have discovered the chemical that makes naked mole rats cancer-proof.
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Renewed hope in a once-abandoned cancer drug class
(American Chemical Society) Could drugs that block the body's system for repairing damage to the genetic material DNA become a boon to health? As unlikely as it may seem, those compounds are sparking optimism as potential treatments for ovarian and breast cancers driven by a mutation in BRCA. The compounds, termed PARP inhibitors, are the topic of the cover story in the current edition of Chemical & Engineering News. C&EN is the weekly newsmagazine of the American Chemical Society, the world's largest scientific society.
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EORTC study opens for elderly patients with HER-2 positive metastatic breast cancer
(European Organisation for Research and Treatment of Cancer) Although the incidence of cancer is higher in persons over 65 years old, we still have an inadequate understanding on how best to treat elderly cancer patients. Elderly patients are occasionally included in clinical trials, but the included patients are mostly healthy, so the broader elderly patient population is not well represented. The EORTC Cancer in the Elderly Task Force has now opened a trial in for elderly patients with HER-2 positive metastatic breast cancer.
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Scientists find new source of versatility so 'floppy' proteins can get things done
(Scripps Research Institute) Many proteins work like Swiss Army knives, fitting multiple functions into their elaborately folded structures. A bit mysteriously, some proteins manage to multitask even with structures that are unfolded and floppy -- "intrinsically disordered." In this week's issue of Nature, scientists at The Scripps Research Institute report their discovery of an important trick that a well-known intrinsically disordered protein uses to expand and control its functionality.
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Scientists awarded $1.4 million to develop new therapeutic approaches to chronic leukemia
(Scripps Research Institute) Scientists from the Florida campus of The Scripps Research Institute have been awarded more than $1.4 million from the National Cancer Institute of the National Institutes of Health to create a potential new drug to attack the malignant cells that cause chronic lymphocytic leukemia, the most common leukemia in the Western world.
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An article in 'Cell' reveals a new resistance mechanism to chemotherapy in breast and ovarian cancer
(Centro Nacional de Investigaciones Oncologicas (CNIO)) The team led by Spanish National Cancer Research Centre researcher Óscar Fernández-Capetillo, head of the Genomic Instability Group, together with researchers from the National Cancer Institute in the US, have participated in a study that describes the causes that explain why tumors with BRCA1 and BRCA2 mutations stop responding to PARP inhibitor drugs.
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UT Dallas study suggests new approach to fight lung cancer
(University of Texas at Dallas) Recent research has shown that cancer cells have a much different -- and more complex -- metabolism than normal cells. Now, scientists at the University of Texas at Dallas have found that exploiting these differences might provide a new strategy to combat lung cancer.
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Lauren Sciences independently recognized as a Technology Innovator in Drug Delivery with its V-Smart Platform, and selected as a Featured Company, in new report by MCD Group
(Lauren Sciences LLC) Lauren Sciences, a privately-held biotechnology company furthering development of its novel V-Smart nanovesicle platform technology, announced today that it was independently recognized as a Technology Innovator in Drug Delivery with its V-Smart Platform, and selected as a Featured Company, in new report by MCD Group.
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Scientists catch EGFR passing a crucial message to cancer-promoting protein
(University of Texas M. D. Anderson Cancer Center) Researchers have discovered and mapped the signaling network between two previously unconnected proteins, exposing a link that, if broken, could cut off cancer cell growth at its starting point.
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Study shows how the Nanog protein promotes growth of head and neck cancer
(Ohio State University Medical Center) Researchers have identified a biochemical pathway in cancer stem cells that is essential for promoting head and neck cancer. The study shows that a protein called Nanog, which is normally active in embryonic stem cells, promotes the growth of cancer stem cells in head and neck cancer. The findings provide information essential for designing novel targeted drugs that might improve the treatment of head and neck cancer.
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Chemical probe confirms that body makes its own rotten egg gas, H2S, to benefit health
(Southern Methodist University) A new study confirms directly what scientists previously knew only indirectly -- that poisonous "rotten egg" gas hydrogen sulfide is generated by the body's blood vessel cells. Researchers made the confirmation by developing a chemical probe that lights up in reaction to rotten egg gas. The scientists observed the process in real-time through a microscope, said chemist Alexander Lippert, Southern Methodist University, Dallas. "This is going to open up many experiments for scientists," Lippert said.
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Fat cells in breast may connect social stress to triple-negative breast cancer
(University of Chicago Medical Center) Local chemical signals released by fat cells in the mammary gland appear to provide a crucial link between exposure to unrelenting social stressors early in life, and the subsequent development of aggressive breast cancer.
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Preventing eggs' death from chemotherapy
(Northwestern University) Young women who have cancer treatment often lose their fertility because chemotherapy and radiation can damage or kill their immature ovarian eggs, called oocytes. Now, Northwestern Medicine® scientists have found the molecular pathway that can prevent the death of immature ovarian eggs due to chemotherapy, potentially preserving fertility and endocrine function. Scientists achieved this in mice by adding a currently approved chemotherapy drug, imatinib mesylate, to another chemotherapy drug cisplatin.
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OHSU review: Previous studies overstated evidence on Medtronic spinal fusion product
(Oregon Health & Science University) An analysis by the Evidence-based Practice Center at Oregon Health & Science University has found that previously published clinical trial studies about a controversial bone growth product used in spinal surgeries overstated the product's effectiveness.
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Aspirin may fight cancer by slowing DNA damage
(University of California - San Francisco) Aspirin is known to lower risk for some cancers, and a new study led by a UC San Francisco scientist points to a possible explanation, with the discovery that aspirin slows the accumulation of DNA mutations in abnormal cells in at least one pre-cancerous condition.
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NIH scientists find promising biomarker for predicting HPV-related oropharynx cancer
(NIH/National Cancer Institute) Researchers have found that antibodies against the human papillomavirus may help identify individuals who are at greatly increased risk of HPV-related cancer of the oropharynx, which is a portion of the throat that contains the tonsils.
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New medication treats drug-resistant prostate cancer in the laboratory
(The Endocrine Society) A new drug called pyrvinium pamoate inhibits aggressive forms of prostate cancer that are resistant to standard drugs, according to a study conducted in an animal model. The results will be presented Monday at The Endocrine Society's 95th Annual Meeting in San Francisco.
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A new target for cancer drug development
(Harvard University) Harvard Stem Cell Institute researchers have identified in the most aggressive forms of cancer a gene known to regulate embryonic stem cell self-renewal, beginning a creative search for a drug that can block its activity.
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cell energy therapy
We report the publication of a new interesting paper about DCA in the 2011edition of the Interantional Journal of Cancer
Dichloroacetate (DCA) inhibits neuroblastoma growth by specifically acting against malignant undifferentiated cells
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A small molecule from this plant is a newfound anticancer molecule.
The research demonstrating this has been recently published in even in the most prestigious journal Nature (vol 475, 14 july 2011). But there could be more in sight.. a synergy with the DCA?
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DCA promoters recommend taking caffeine and extra thiamine (vitamin B1), hoping that this will help the DCA work better and reduce potential risks of nerve damage. In a survey conducted by the DCA site (www.thedcasite.com) a certain number of heavy tea or coffee drinkers observed astounding responses, even remissions. Here we propose that it could be the sugar contained in those drinks to have helped the DCA mote than, or maybe instead of, caffeine or theophylline.
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In the review paper "Dichloroacetate (DCA) as a potent..." appeared in the Online first session, in September issue of BJP, Prof. Michelakis most interestingly underlines the importance of targeting the peculiar "aerobic glycolytic" metabolic status of tumors. He suggests that the "Warburg effect", as the phenomenon is more commonly known in the literature, can be modulated by unlocking a mitochondrial impairment in cancer cells and that this could be a very promising strategy to fight cancer.
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By itself, metformin was ineffective in treating tumors. In a one-two punch, metformin reduced tumors faster and prolonged remission in mice longer than chemotherapy alone, apparently by targeting cancer stem cells, report Harvard Medical School researchers in the Sept. 14 advance online Cancer Research.
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In the last issue of Translational Oncology (2009, 2, pp. 138-145) a report appeared confirming that cellular bioenergetics is a central issue of investigation in cancer biology.
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DCA is in clinical trials and results are expected with great interest. Meanwhile stories can be heard from people, even read on the internet, that tell us that they or their relatives have benefited from using DCA against cancer expecially when combining it with other treatments.
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